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The Serenity Tavern is a bar in Prophecy Creek, Pennsylvania. The Tavern is named after the Serenity, the 18th century ship that carried the European founders of Prophecy Creek to North America. The Tavern is built from wood taken from the ship.

In 1980, Janice Everett met Leland Foxx at the bar, and spent the night in room 16 of the Gateway Motel. In 1992, the Tavern was purchased by brothers-in-law Vincent Kelerick and Roderigo Messina.