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Serena W. Prentiss (b. 29 Feb 1960) is the wife of Milo Harper, the mother of Theron Harper, the mother-in-law of Bridget Malone, and the grandmother of Mallory Harper. She is a leapling.

She is a resident of Thousand Oaks, California, and works as a Special Agent for the Los Angeles field office of the Federal Bureau of Investigation.